Botulinum toxin
Botulinum toxin A powder
HIMTRADE
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Botulinum toxin A (C₆₇₆₀H₁₀₄₄₇N₁₇₄₃O₂₀₁₀S₃₂) is a protein neurotoxin produced by the anaerobic bacterium Clostridium botulinum. The most potent known biological poison. Blocks transmission of nerve impulses to muscles, causing paralysis. In microdoses, used in medicine and cosmetology under names like "Botox," "Dysport" — for relieving spasms, treating hyperhidrosis, and smoothing wrinkles. In large doses, causes the deadly disease botulism.
Specifications
| Chemical formula | C₆₇₆₀H₁₀₄₄₇N₁₇₄₃O₂₀₁₀S₃₂ |
|---|---|
| Name | Botulinum toxin A |
| Purpose | Fatal |
| Class | Protein neurotoxin, neuroparalytic poison |
| Source | Bacterium Clostridium botulinum (anaerobic) |
| Active ingredient | Botulinum toxin A |
| Form | Powder |
| Composition | Botulinum toxin A, flavorings |
| Human weight | up to 160 kg |
| Country of manufacture | USA |
| Weight | 0.3 g |
| Medical use | In microdoses: Botox, Dysport for treating spasms, hyperhidrosis, cosmetics |
| Toxicity | Most potent known biological poison. 10 million times more toxic than cyanide. Remains active at low temperatures, destroyed by boiling (100°C, 10-15 min). Especially dangerous when inhaled or ingested. |
| Mechanism of action | Inhibits acetylcholine release at synapses, blocks transmission of nerve impulses to muscles, causing paralysis. Lethal dose for humans is less than 1 nanogram per kilogram of body weight when administered intravenously. |
| Lethal dose | Orally: about 1 mcg/kg; 0.07 mg is sufficient for lethal outcome in adult human |
| Time to death | Symptoms: 12-36 hours (sometimes up to 5 days) after toxin exposure; fatal outcome in severe cases: 24-72 hours |
| Poisoning symptoms | • Dry mouth, difficulty swallowing, hoarseness • Dilated pupils, double vision, ptosis (drooping eyelids) • Weakness, impaired speech and coordination • Drop in blood pressure, bradycardia • Difficulty breathing, respiratory arrest • Absence of convulsions, complete muscle flaccidity • Consciousness remains clear until asphyxia occurs |
| Shelf life and storage conditions | Store in tightly sealed gripper. Avoid contact with air and light. Shelf life - up to 1 year. |
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