Anisatin
Anisatin powder
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Anisatin (C₁₅H₂₀O₈) is a neurotoxic terpene found in the fruits of Illicium anisatum (Japanese star anise, not to be confused with edible star anise Illicium verum). Used only in toxicological research and pharmacological toxicometry. Not used in cooking or medicine. Poisonings often occur from accidental consumption of Japanese star anise instead of the edible variety.
Specifications
| Chemical formula | C₁₅H₂₀O₈ |
|---|---|
| Name | Anisatin |
| Purpose | Fatal |
| Class | Neurotoxic terpene, GABA receptor antagonist |
| Source | Illicium anisatum (Japanese star anise, not to be confused with edible star anise Illicium verum) |
| Active ingredient | Anisatin |
| Form | Powder |
| Composition | Anisatin, flavoring, inhibitor |
| Human weight | up to 150 kg |
| Country of manufacture | Japan |
| Weight | 1 g |
| Application area | Toxicological research, pharmacological toxicometry |
| Lethal dose | 5-10 mg/kg body weight; 0.3-0.5 g dried Illicium anisatum fruits for adult |
| Time to death | Severe poisoning: 1-3 hours after ingestion |
| Mechanism of action | Potent antagonist of GABA receptors (gamma-aminobutyric acid) in CNS. Causes uncontrolled neuronal excitation, convulsions, and respiratory muscle spasms. Severely irritates gastrointestinal tract. |
| Poisoning symptoms | • Severe nausea, vomiting, abdominal pain • Dizziness, tremor, disorientation • Convulsions (clonic-tonic), hyperthermia • Rapid breathing, tachycardia, cyanosis • In severe cases - coma, respiratory arrest |
| Toxicity | High toxicity even at small doses. Toxic when ingested, inhaled, or upon contact with mucous membranes. Death occurs due to convulsive respiratory paralysis or cardiac arrest. |
| Shelf life and storage conditions | Store in tightly sealed gripper. Protect from light, moisture, and air. Shelf life - up to 2 years under airtight conditions. |
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